SYDNEY, January 19, 2016 /PRNewswire/ --
606-patient MORE Study Sub-Group Analysis Examined Outcomes for Elderly (greater than or equal to70 years) and Very Elderly (greater than or equal to75 years) Patients with
Liver-Dominant Metastatic Colorectal Cancer (mCRC)
A new analysis of the MORE data on 606 mCRC patients treated with SIR-Spheres Y-90 resin microspheres at 11 U.S. medical centres, published late last year in the journal Clinical Colorectal Cancer, confirms that patient age is not a barrier to appropriate treatment with SIR-Spheres(R) Y-90 resin microspheres, Sirtex reported today.
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"The analysis of the data from the MORE study confirmed that age alone should not exclude patients from being considered for, or receiving, SIR-Spheres(R) Y-90 resin microspheres treatment," said principal study author, Andrew S. Kennedy, MD, Director, Radiation Oncology Research, Sarah Cannon Research Institute. "Because older mCRC patients tend to receive less intense systemic therapy, local liver tumour control with selective internal radiation therapy, or radioembolisation, may provide added benefits to this population. We look forward to continuing our research in this field to determine the most effective treatments for this patient population and improve outcomes."
The new MORE analysis divided the 606-patient population into two groups, 446 patients under age 70 years at the time of treatment and 160 patients age 70 years or older when treated. Researchers also separately analysed the data for 90 very elderly patients who were age 75 and above. Mean ages in the younger, elderly, and very elderly groups were 55.9 +/- 9.4 years, 77.2 +/- 4.8 years, and 80.2 +/- 3.8 years, respectively. The researchers found that regardless of their age, the patients tended to have similar baseline characteristics.
However, the elderly patients were more likely (P