HATFIELD, England, December 8, 2015 /PRNewswire/ --
PRESS RELEASE FOR RUSSIAN MEDIA ONLY: NOT FOR AUSTRIA/SWISS/U.S. JOURNALISTS
New anti-convulsant treatment to reduce serious seizures for idiopathic generalised
epilepsy, now available in Russia
Fycompa(R) (perampanel), a convenient, once-daily epilepsy treatment, launches in Russia today, for primary generalised tonic-clonic (PGTC) seizures in adults and adolescents (greater than or equal to12 years) with idiopathic generalised epilepsy (IGE).  The number of anti-epileptic drugs (AEDs) licensed for the treatment of PGTC seizures is limited and as many as 20 percent (%) of people with idiopathic generalised epilepsy (IGE) remain uncontrolled, despite treatment. Perampanel is the first new treatment for PGTC seizures in IGE in five years.
There are approximately 496, 920 people in Russia with epilepsy; one third of these have idiopathic generalised epilepsy and approximately 60% of these (103,525 people), will experience PGTC seizures.,, Perampanel offers clinicians a first-in-class treatment that reduces PGTC seizures, which are dangerous epileptic events. These seizures increase the risk of injury, such as fractured bones, shoulder dislocation and burns. PGTC seizures also increase the risk of sudden unexplained death in epilepsy (SUDEP) and are known to lead to atypical absence status epilepticus (ASE), seizures that may last for extended time periods.
"Primary generalised tonic-clonic seizures can cause serious injuries and can even be fatal. The availability of perampanel, which reduces the frequency of seizures, is welcome news for Russian people aged 12 years and over and living with this form of epilepsy," comments Elena Belousova, Director of Psychoneurology and Epileptology, Moscow Research Institute of Paediatrics.
Grand mal (PGTC) seizures start with a loss of consciousness and a sudden contraction of the muscles, which can cause the person to fall down (tonic phase). This is followed by violent convulsions (clonic phase) until the muscles finally relax. While the seizure generally lasts a few minutes, the person will often feel confused or drowsy for up to a few minutes or up to a few hours, before returning to normal.
Perampanel is the first-and-only licensed AED to selectively target the initiation and spread of seizures through inhibition of AMPA receptors, a protein in the brain which plays a critical role in the spread of seizures. Perampanel is also indicated for the adjunctive treatment of partial-onset seizures, with or without secondarily generalised seizures, in patients with epilepsy aged 12 years and older.
One third more patients experienced a reduction in seizure frequency with perampanel over 28 days versus placebo (50% responder rate 64.2% vs 39.5%, respectively; P=0.0019).  Perampanel demonstrates a reduction in PGTC seizure frequency (per 28 days) versus placebo (76.5% vs 38.4%, respectively; P4 years. (Rufinamide was originally developed by
- Zonegran(R) (zonisamide) as monotherapy in the treatment of partial seizures, with or
without secondary generalisation, in adults with newly diagnosed epilepsy and as
adjunctive therapy in the treatment of partial seizures, with or without
generalisation, in adults, adolescents and children aged six years and above.
(Zonegran is under license from the originator Dainippon Sumitomo Pharma).
- Zebinix(R) (eslicarbazepine acetate) as adjunctive therapy in adult patients with
partial onset seizures, with or without secondary generalisation. (Zebinix is under
license from BIAL).
About Eisai Co., Ltd.
Eisai Co., Ltd. is a leading global research and development-based pharmaceutical company headquartered in Japan. We define our corporate mission as "giving first thought to patients and their families and to increasing the benefits health care provides," which we call our human health care (hhc) philosophy. With over 10,000 employees working across our global network of R&D facilities, manufacturing sites and marketing subsidiaries, we strive to realise our hhc philosophy by delivering innovative products in multiple therapeutic areas with high unmet medical needs, including Oncology and Neurology.
As a global pharmaceutical company, our mission extends to patients around the world through our investment and participation in partnership-based initiatives to improve access to medicines in developing and emerging countries.
For more information about Eisai Co., Ltd., please visit http://www.eisai.com.
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Date of preparation: July 2015
Job code: Fycompa-UK0211
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