MADRID, June 24, 2017 /PRNewswire/ --
Hodgkin lymphoma is the most common malignancy of young adults. Intensive chemotherapy with eight or six cycles of eBEACOPP is very effective in patients with advanced-stage Hodgkin's lymphoma (HL), albeit at the expense of severe toxicities. Aiming at better tolerability, we investigated whether metabolic response determined by positron emission tomography after two cycles (PET-2) would allow us to select patients, who could be treated with reduced intensity (four cycles) without loss of efficacy.
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The GHSG HD18 trial was conducted in five European countries (Germany, Switzerland (SAKK), Austria (AGMT), Czech Republic, the Netherlands). Between 05/2008 and 07/2014, 2101 patients aged 18-60 years with newly diagnosed, advanced-stage HL were recruited, of whom 1005 were PET-2 negative.
Reduced therapy with four cycles of eBEACOPP was non-inferior to 6/8 cycles in terms of five-year progression-free survival (92.2% versus 90.8%, difference +1.4%, 95% CI -2.7-5.4). We observed no treatment related mortality in the experimental group, fewer infections, less organ toxicities and a very low incidence of second acute myeloid leukemia. Overall, this resulted in a significantly superior five-year overall survival (97.7% versus 95.4%, log-rank p=0.004) for the patient cohort with reduced treatment.
In conclusion, treatment with four cycles of eBEACOPP in patients with negative PET-2 is extremely effective, very safe, short (12 weeks), and affordable. Results for efficacy and safety compare favorably with any other published treatment strategy.
We therefore recommend PET-2-guided eBEACOPP for patients with advanced-stage HL.
Presenter: Dr Peter Borchmann
Affiliation: Uniklinik Koeln, Cologne, Germany
Topic: TREATMENT REDUCTION IN PATIENTS WITH ADVANCED-STAGE HODGKIN LYMPHOMA AND NEGATIVE INTERIM PET: FINAL RESULTS OF THE INTERNATIONAL, RANDOMIZED PHASE 3 TRIAL HD18 BY THE GERMAN HODGKIN STUDY GROUP
Abstract S150 will be presented by Peter Borchmann on Friday, June 23 15:45 - 17:00 in Hall A.
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