Adults with Type 2 Diabetes Treated with Xultophy® (IDegLira) were up to 4.5 Times More Likely to Reach Glycaemic Targets Without Hypoglycaemia and Weight Gain vs Up-titration with Insulin Glargine U100

MUNICH, Germany, September 13, 2016 /PRNewswire/ --

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Novo Nordisk today presented data showing the odds of reaching fasting plasma glucose (FPG) targets without hypoglycaemia and weight gain were significantly greater for Xultophy(R) (IDegLira) compared to up-titration with insulin glargine U100 in adults with type 2 diabetes uncontrolled on insulin glargine U100 (20-50 units). Xultophy(R) is the first once-daily combination of a long-acting insulin (insulin degludec) and a glucagon-like peptide-1 (GLP-1) receptor agonist (liraglutide) in Europe. Results were presented at the 52nd Annual Meeting of the European Association for the Study of Diabetes (EASD) 2016.[1]

The post-hoc analysis of the DUAL V phase 3b trial was evaluated using a FPG target of 7.2 mmol/L, selected to better reflect targets used in clinical practice.[2] Data showed that adults treated with Xultophy(R) were 4.55 times more likely to reach FPG targets without confirmed hypoglycaemia and weight gain vs up-titration with insulin glargine U100 (41.4% vs 14.3%, p7.5-less than or equal to8.5 and >8.5%) with Xultophy(R) vs up-titration with insulin glargine U100 (51% vs 25%; 39% vs 11%; 32% vs 5%; p8.5%) with Xultophy(R) vs up-titration with insulin glargine U100 (51% vs 25%; 39% vs 11%; 32% vs 5%; p

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