Norgine Welcomes the New World Health Organisation (WHO) ICD-11 Coding for Hepatic Encephalopathy[i]

AMSTERDAM, July 3, 2018 /PRNewswire/ --

Norgine announced today that it welcomes the inclusion of hepatic encephalopathy in the new WHO release of the International Classification of Diseases (ICD-11).

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ICD purpose and uses: 

ICD is the foundation for the identification of health trends and statistics globally, and the international standard for reporting diseases and health conditions. It is the diagnostic classification standard for all clinical and research purposes. ICD defines the universe of diseases, disorders, injuries and other related health conditions, listed in a comprehensive, hierarchical fashion that allows for:

- easy storage, retrieval and analysis of health information for evidenced-based
- sharing and comparing health information between hospitals, regions, settings and
countries; and
- data comparisons in the same location across different time periods.

Uses include monitoring of the incidence and prevalence of diseases, observing reimbursements and resource allocation trends, and keeping track of safety and quality guidelines. They also include the counting of deaths as well as diseases, injuries, symptoms, reasons for encounter, factors that influence health status, and external causes of disease.

The new ICD code for hepatic encephalopathy is DB99.5. 

Dr Alastair Benbow, Chief Development & Medical Officer at Norgine said: "Including hepatic encephalopathy, a common complication of liver cirrhosis, in the ICD-11 is a significant milestone which should help improve diagnosis and treatment of this debilitating disease and ultimately reduce societal and health economic burden."

He added: "Europe has the largest burden of liver disease in the world and, in some countries such as the UK and Finland the increase in liver deaths over the past 40 years was reported as "staggering'.[ii] While we appreciate that implementation of the ICD-11 will take some time, we believe that it will help to recognise that hepatic encephalopathy is a life-threatening condition and that patients can be managed accordingly."

Norgine currently holds marketing rights for rifaximin-alpha (XIFAXAN(R) 550mg, also known as TARGAXAN(R) 550mg in the UK and Belgium) in Australia, Belgium, Denmark, Finland, Germany, Luxembourg, Netherlands, New Zealand, Norway, Republic of Ireland, Sweden and United Kingdom.

XIFAXAN(R) 550mg is indicated for the reduction in risk of overt hepatic encephalopathy (HE) recurrence in patients greater than or equal to18 years of age. 

GL/XIF/0718/0191 [ ]

View the full media release on

i. World Health Organisation. ICD-11. Accessed 21 June 2018

ii. Pimpin, L., Cortez-Pinto, H., Negro, F., Corbould, E., Lazarus, J.V., Webber, L., Sheron, N., Burden of liver disease in Europe: epidemiology and analysis of risk factors to identify prevention policies, Journal of Hepatology (2018), doi:

Media Contact :  Isabelle Jouin, T : +44(0)1895-826237 Follow us @norgine


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